This is a dry lab focused training program on variant analysis and interpretation of Next Generation Sequencing NGS data. The program combines foundational concepts with hands-on case analysis to prepare trainees for accurate and effective genomic analysis and interpretation.
The structured 8-week curriculum progresses from foundational concepts such as molecular biology and basic human genetics to NGS – overview, workflow and data QC. It also includes sessions on genomic clinical databases, genotypic-phenotypic correlation, HGVS nomenclature, and in-silico prediction tools for variant annotation and interpretation. The program combines theoretical learning, hands-on exercises, assignments, group presentations, and competency assessments to prepare trainees for genomic analysis and reporting.
As part of this program, trainees also receive dedicated training in somatic variant analysis with a focus on oncology, covering the distinct principles of somatic variant identification, prioritisation and classification within a clinical oncology context alongside extensive hands-on training on germline variant interpretation and analysis.
Duration –8 weeks full-time, structured curriculum
Format–Theory sessions, hands-on exercises, case-based assignments, group
presentations.
Core Topics –Molecular biology Human genetics Cytogenetics Karyotyping FISH PCR Sanger sequencing MLPA Microarray analysis NGS workflows QC Variant databases annotation tools ACMG-based SNV classification and prioritisation CNV analysis classification and prioritisation AMP guidelines based NGS data solid tumorhemato-oncology somatic variant analysis
Specialized Focus–Germline Mendelian and hereditary cancers and somatic tumor and hemato-onco specific variant analysis, interpretation, prioritisation and classification
Training -Trial sample analysis, variant visualization IGV, case discussions, and competency-based evaluations
Assessment –Periodic MCQs, assignments, group presentations, and a structured final evaluation
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